About: Interferon Alpha-Beta Receptor Alpha Chain     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Interferon Alpha-Beta Receptor Alpha Chain
equivalentClass
OMIM_Number
  • 107450
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • Interferon Alpha-Beta Receptor Alpha Chain
UMLS_CUI
  • C0380190
Legacy_Concept_Name
  • Interferon_Alpha-Beta_Receptor_Alpha_Chain
FULL_SYN
  • AVPSYNCI
  • IFN-Alpha-RECSYNCI
  • Interferon Alpha ReceptorSYNCI
  • HuIFN-Alpha-RecSYNCI
  • IFRCSYNCI
  • IFNBRSYNCI
  • Alpha-Beta-Omega Interferon Receptor-1SYNCI
  • Antiviral Protein Alpha TypeSYNCI
  • Interferon Alpha-Beta Receptor Alpha ChainPTNCI
Swiss_Prot
  • P17181
DEFINITION
  • IFN alpha-beta receptor alpha chain (557 aa, 64 kD) is a cell communication protein that is encoded by the human IFNAR1 gene and has a role in signal transduction.NCI
DesignNote
  • Encoded by human IFNAR1 Gene (Type II Cytokine Receptor Family), 557-aa 64-kDa (precursor) ubiquitous type I membrane protein Interferon Alpha-Beta Receptor Alpha Chain contains 3 fibronectin type III domains and is the alpha subunit of Interferon Alpha Receptor Complex, a heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2.
code
  • C37276
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