About: ZBTB16-RARA Fusion Protein Expression     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • ZBTB16-RARA Fusion Protein Expression
rdfs:subClassOf
Semantic_Type
  • Cell or Molecular Dysfunction
Preferred_Name
  • ZBTB16-RARA Fusion Protein Expression
UMLS_CUI
  • C1518796
Legacy_Concept_Name
  • PLZF-RARalpha_Fusion_Protein_Expression
FULL_SYN
  • PLZF/RARA Fusion Protein ExpressionSYNCI
  • ZBTB16-RARA Fusion Protein ExpressionPTNCI
  • ZBTB16/RARA Fusion Protein ExpressionSYNCI
  • PLZF-RARalpha Fusion Protein ExpressionSYNCI
DEFINITION
  • A fusion protein encoded by a t(15;17) translocation, which involves the human genes ZBTB16 and RARA and is characteristic of acute promyelocytic leukemia. It is a transcriptional repressor with both gain-of-function and dominant-negative properties, resulting in transcriptional repression of retinoic acid and non-retinoic acid target genes and culminating in differentiation arrest.NCI
code
  • C37220
is someValuesFrom of
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