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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Cholera Toxin
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Hazardous or Poisonous Substance
Preferred_Name
  • Cholera Toxin
UMLS_CUI
  • C0008356
CAS_Registry
  • 9012-63-9
Legacy_Concept_Name
  • Cholera_Toxin
FULL_SYN
  • Cholera ToxinPTNCI
DEFINITION
  • Secreted by Vibrio cholerae, Cholera Toxin is a natural bacterial enterotoxin consisting of major components heavy A- and light B peptides (choleragenoid) that initiates a signaling cascade in intestinal epithelial cells causing a dysfunction of chloride channels, loss of water, and diarrhea. B peptide anchors the protein to epithelia; A peptide enters the cytoplasm and activates adenylate cyclase. Due to its cytotoxicity, cholera toxin is being studied for tumor cell targeting and cancer chemotherapy. (NCI04)NCI
code
  • C368
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