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AttributesValues
rdf:type
rdfs:label
  • Cephalothin Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Cephalothin Sodium
UMLS_CUI
  • C0037490
CAS_Registry
  • 58-71-9
FDA_UNII_Code
  • C22G6EYP8B
Contributing_Source
  • FDA
ALT_DEFINITION
  • A cephalosporin antibiotic.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39181
PDQ_Closed_Trial_Search_ID
  • 39181
Chemical_Formula
  • C16H15N2O6S2.Na
Legacy_Concept_Name
  • Cephalothin
CHEBI_ID
  • CHEBI:3542
FULL_SYN
  • KeflinBRNCI
  • Cephalothin SodiumPTNCI
  • CEPHALOTHIN SODIUMPTFDAC22G6EYP8B
DEFINITION
  • The sodium salt form of cephalothin, a semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.NCI
code
  • C358
is Has_Salt_Form of
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