About: Ceftazidime Sodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ceftazidime Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Ceftazidime Sodium
UMLS_CUI
  • C0700860
CAS_Registry
  • 78439-06-2
FDA_UNII_Code
  • CMC30V039K
Contributing_Source
  • FDA
ALT_DEFINITION
  • Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39179
PDQ_Closed_Trial_Search_ID
  • 39179
Chemical_Formula
  • C22H21N6O7S2.Na
Legacy_Concept_Name
  • Ceftazidime
FULL_SYN
  • Ceftazidime SodiumPTNCI
  • TazicefBRNCI
  • CEFTAZIDIME SODIUMPTFDACMC30V039K
DEFINITION
  • The sodium salt of ceftazidime, a third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis. Compared to the second and first generation cephalosporins, ceftazidime is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftazidine also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS). PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity.NCI
code
  • C355
is someValuesFrom of
is Has_Salt_Form of
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