About: Carmustine

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Attributes	Values
rdf:type	Class
rdfs:label	Carmustine
rdfs:subClassOf	DNA Adduct Forming Agent Nitrosourea Compounds
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Hazardous or Poisonous Substance
Preferred_Name	Carmustine
NSC_Code	409962
UMLS_CUI	C0007257
CAS_Registry	154-93-8
Accepted_Therapeutic_Use_For	Brain tumors; colon cancer; lung cancer; lymphomas; Hodgkins and Non-Hodgkins; melanoma; multiple myeloma; mycosis fungoides
In_Clinical_Trial_For	Chronic myelogenous leukemia; CNS cancer; cutaneous T-cell lymphoma; gliomas; lymphoma; Hodgkins and non-Hodgkins; multiple myeloma
FDA_UNII_Code	U68WG3173Y
Contributing_Source	FDA
ALT_DEFINITION	An anticancer drug that belongs to the family of drugs called alkylating agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID	43027
PDQ_Closed_Trial_Search_ID	43027
Chemical_Formula	C5H9Cl2N3O2
Legacy_Concept_Name	Carmustine
CHEBI_ID	CHEBI:3423
FULL_SYN	1,3-Bis(2-chloroethyl)-1-nitrosoureaSNNCI N,N'-bis(2-chloroethyl)-N-nitrosoureaSNNCI BCNUABNCI 1,3-Bis(beta-chloroethyl)-1-nitrosoureaSNNCI FDA 0345CNNCI SK 27702CNNCI SRI 1720CNNCI CarmustinSYNCI BCNUSYDTPNSC0409962 CarmustinumFBNCI carmustinePTNCI-GLOSSCDR0000045976 BiCNUBRNCI N,N'-Bis(2-chloroethyl)-N-nitrosoureaSYDTPNSC0409962 NitrumonSYDTPNSC0409962 Bis(chloroethyl) NitrosoureaSYNCI GliadelBRNCI BecenunFBNCI BecenumBRNCI CarmubrisSYDTPNSC0409962 CARMUSTINEPTFDAU68WG3173Y NitrumonFBNCI WR-139021CNNCI CarmubrisBRNCI Bis-ChloronitrosoureaSYNCI CarmustinePTNCI NitroureanFBNCI
DEFINITION	An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)NCI
code	C349
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