About: Placental TGF-Beta     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Placental TGF-Beta
equivalentClass
OMIM_Number
  • 605312
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Placental TGF-Beta
UMLS_CUI
  • C0668195
Legacy_Concept_Name
  • Placental_TGF-Beta
FULL_SYN
  • NRG1SYNCI
  • Macrophage Inhibitory Cytokine-1SYNCI
  • Placental Bone Morphogenic ProteinSYNCI
  • NSAID-Activated Protein 1SYNCI
  • NSAID-Regulated Protein 1SYNCI
  • PDFSYNCI
  • Nonsteroidal Anti-Inflammatory Drug-Activated Protein 1SYNCI
  • NAG1SYNCI
  • MIC1SYNCI
  • GDF15SYNCI
  • PTGFBSYNCI
  • Placental TGF-BetaPTNCI
  • PTGF-BetaSYNCI
  • Prostate Differentiation FactorSYNCI
  • Growth/Differentiation Factor 15SYNCI
Swiss_Prot
  • Q99988
DEFINITION
  • Expressed in activated, but not resting, macrophages and in placenta, prostate, colon, and kidney by human PLAB Gene (BMP/TGF-Beta Family), 308-aa 34-kDa (precursor) Placental TGF-Beta is processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in a disulfide-linked homodimeric secreted mature protein of 224 amino acids. PLAB regulates tissue differentiation and maintenance and reduces the growth of granulocytes and macrophages. Unlike most TGFB superfamily members, in which the amino acid sequence is completely conserved, PLAB shares only 70% amino acid identity with its rodent counterparts. (NCI)NCI
code
  • C34026
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