About: AF-6 Protein

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Attributes	Values
rdf:type	Class
rdfs:label	AF-6 Protein
rdfs:subClassOf	Actin-Binding Protein nodeID://b642087
OMIM_Number	159559
Semantic_Type	Amino Acid, Peptide, or Protein
Preferred_Name	AF-6 Protein
UMLS_CUI	C0381251
Legacy_Concept_Name	AF-6_Protein
FULL_SYN	AF-6 ProteinPTNCI AF6SYNCI MLLT4SYNCI Trithorax Homolog 4SYNCI
Swiss_Prot	P55196
DEFINITION	Expressed in a variety of cell types by human MLLT4 Gene, 1816-aa 206-kDa AF-6 Protein is a possible signal transduction protein controlled by Ras signaling pathways that is strongly similar to afadin (rat) and contains short stretches rich in proline, charged amino acids, serines, or glutamines, 1 dilute domain, 1 FHA domain, 1 PDZ/DHR domain, and 2 RAS-associating domains. Shared with several vertebrate and invertebrate proteins, the MLLT4 GLGF motif may be involved in signal transduction at special cell-cell junctions. MLLT4 binds directly to ZO-1 and occludin. MLLT4 may bind to actin filaments, linking the actin cytoskeleton to the plasma membrane at cell-to-cell adherens junctions. A common acute leukemia chromosomal translocation t(6;11)(q27;q23) involves fusion of MLLT4 and MLL/HRX that results in production of a rogue activator protein.NCI
code	C33946

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