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AttributesValues
rdf:type
rdfs:label
  • Multiple Endocrine Neoplasia Type 1
equivalentClass
Semantic_Type
  • Neoplastic Process
Preferred_Name
  • Multiple Endocrine Neoplasia Type 1
UMLS_CUI
  • C0025267
ALT_DEFINITION
  • A rare syndrome characterized by hyperplasia and/or neoplasms of the pituitary, parathyroid glands, and pancreatic islets. Hyperparathyroidism occurs in 90% of the cases and is usually the first manifestation of the syndrome. The most frequent pancreatic manifestation is gastrinoma typically leading to Zollinger-Ellison Syndrome. The appearance of this condition has been limited to the loss of allelic heterozygosity at the 11q13 locus on the long arm of chromosome 11. Patients overall exhibit long survival times. Chemotherapy is rare and surgical management is generally dependent on the genetic expression in individual patients. (From Holland et al., Cancer Medicine, 3d ed, pp1169-72)MSH2003_2003_05_12
  • A rare, inherited disorder that affects the endocrine glands and can cause tumors in the parathyroid and pituitary glands and the pancreas. These tumors are usually benign (not cancer). They cause the glands to secrete high levels of hormones, which can lead to other medical problems, such as kidney stones, fertility problems, and severe ulcers. In some cases, tumors inside the pancreas can become malignant (cancer).NCI-GLOSS
Neoplastic_Status
  • Undetermined
Legacy_Concept_Name
  • Multiple_Endocrine_Neoplasia_Type_I
FULL_SYN
  • multiple endocrine neoplasia type 1 syndromePTNCI-GLOSSCDR0000270861
  • Multiple Endocrine Neoplasia Type 1PTNCI
  • Multiple Endocrine Neoplasia Type ISYNCI
  • Multiple Endocrine Neoplasia, Type ISYNCI
  • Wermer SyndromeSYNCI
  • MEN1 syndromePTNCI-GLOSSCDR0000270862
  • MEN 1ABNCI
  • Multiple Endocrine Adenomatosis Type 1SYNCI
  • Multiple Endocrine Adenomatosis Type ISYNCI
  • Wermer's SyndromeSYNCI
  • Multiple Endocrine Adenomatosis, Type ISYNCI
  • Wermer syndromePTNCI-GLOSSCDR0000270864
  • MEA Type 1ABNCI
  • MEN Type 1ABNCI
  • MEA Type IABNCI
  • MEN Type IABNCI
DEFINITION
  • Multiple endocrine neoplasia caused by inactivation of the tumor suppressor gene MEN-1. Patients may develop hyperparathyroidism and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell neoplasms, and carcinoid tumors.NCI
code
  • C3225
is someValuesFrom of
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