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AttributesValues
rdf:type
rdfs:label
  • Immediate Hypersensitivity
rdfs:subClassOf
Semantic_Type
  • Disease or Syndrome
Preferred_Name
  • Immediate Hypersensitivity
UMLS_CUI
  • C0020523
ALT_DEFINITION
  • Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.MSH2003_2003_05_12
Legacy_Concept_Name
  • Immediate_Hypersensitivity
FULL_SYN
  • Immediate HypersensitivityPTNCI
DEFINITION
  • Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.NCI
code
  • C3116
is rdfs:subClassOf of
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