About: Yolk Sac Tumor

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Attributes	Values
rdf:type	Class
rdfs:label	Yolk Sac Tumor
equivalentClass	nodeID://b641366
Concept_In_Subset	Clinical Data Interchange Standards Consortium Terminology CDISC SDTM Terminology CDISC SEND Terminology CDISC SEND Tumor Findings Results Terminology
Semantic_Type	Neoplastic Process
Preferred_Name	Yolk Sac Tumor
UMLS_CUI	C0014145
Contributing_Source	CDISC
ALT_DEFINITION	An unusual and aggressive tumor of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumor found in children. It is characterized by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (Schiller-Duval body). The tumor is rarely bilateral. Before the use of combination chemotherapy, the tumor was almost invariably fatal. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1189)MSH2003_2003_05_12 A non-seminomatous malignant germ cell tumor composed of primitive germ cells and which produce an eosinophilic substance (alpha-fetoprotein).CDISC
ICD-O-3_Code	9071/3
Neoplastic_Status	Malignant
Legacy_Concept_Name	Yolk_Sac_Tumor
FULL_SYN	Endodermal Sinus TumorSYNCI ENDODERMAL SINUS TUMORSYCDISC Yolk Sac TumorPTNCI Endodermal Sinus NeoplasmSYNCI YOLK SAC TUMOR, MALIGNANTPTCDISC ENDODERMAL SINUS NEOPLASMSYCDISC Yolk Sac TumorSYNCITCGA Yolk Sac NeoplasmSYNCI YOLK SAC NEOPLASMSYCDISC YOLK SAC TUMOR SITE UNSPECIFIEDSYCDISC Yolk Sac Tumour Site UnspecifiedSYNCI
DEFINITION	A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum.NCI
code	C3011
is rdf:first of	nodeID://b730253 nodeID://b730254 nodeID://b730255 nodeID://b730256 nodeID://b730257 nodeID://b730258 nodeID://b730259 nodeID://b730260 nodeID://b730261
is someValuesFrom of	nodeID://b723987

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