About: Toll-Like Receptor 7     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Toll-Like Receptor 7
equivalentClass
OMIM_Number
  • 300365
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • Toll-Like Receptor 7
UMLS_CUI
  • C0971207
Legacy_Concept_Name
  • Toll-Like_Receptor-7
FULL_SYN
  • TLR7SYNCI
  • Toll-Like Receptor 7PTNCI
Swiss_Prot
  • Q9NYK1
DEFINITION
  • Expressed in lung, placenta, spleen, brain, stomach, small intestine, and pre-dendritic cells by human TLR7 Gene (TLR Family), 104-aa 121-kDa (precursor) type I membrane protein Toll-Like Receptor 7 contains a TIR domain and 27 LRR repeats. TLR7 has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR7 likely acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. (NCI)NCI
code
  • C30108
is someValuesFrom of
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