About: Experimental Allergic Encephalomyelitis     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Experimental Allergic Encephalomyelitis
rdfs:subClassOf
Semantic_Type
  • Experimental Model of Disease
Preferred_Name
  • Experimental Allergic Encephalomyelitis
UMLS_CUI
  • C0014072
ALT_DEFINITION
  • An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)MSH2003_2003_05_12
Legacy_Concept_Name
  • Experimental_Allergic_Encephalomyelitis
FULL_SYN
  • EAESYNCI
  • Experimental Allergic EncephalomyelitisPTNCI
  • Experimental Autoimmune EncephalomyelitisSYNCI
DEFINITION
  • An autoimmune demyelinating disease of the central nervous system that is produced experimentally in animals by the injection of homogenized brain or spinal cord in Freund's adjuvant. Myelin basic protein appears to be the antigen that elicits the hypersensitivity immune response which is characterized by focal areas of lymphocyte and macrophage infiltration into the brain, associated with demyelination and destruction of the blood-brain barrier. Experimental allergic encephalomyelitis (EAE) is used as an animal model for demyelinating diseases of the human central nervous system such as multiple sclerosis.NCI
code
  • C3006
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