About: Receptor-Interacting Serine/Threonine-Protein Kinase 2     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Receptor-Interacting Serine/Threonine-Protein Kinase 2
equivalentClass
OMIM_Number
  • 603455
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Receptor-Interacting Serine/Threonine-Protein Kinase 2
UMLS_CUI
  • C0759447
Legacy_Concept_Name
  • Receptor-Interacting_Serine-Threonine_Protein_Kinase-2
FULL_SYN
  • EC 2.7.10.2SYNCI
  • EC 2.7.11.1SYNCI
  • RIP-Like Interacting CLARP KinaseSYNCI
  • RIP-Like-Interacting CLARP KinaseSYNCI
  • CARD-Containing Interleukin-1 Beta Converting Enzyme Associated KinaseSYNCI
  • Receptor-Interacting Serine/Threonine Protein Kinase 2SYNCI
  • Receptor-Interacting Serine/Threonine-Protein Kinase 2PTNCI
  • CARD-Containing IL-1 Beta Ice-KinaseSYNCI
  • RIP2SYNCI
  • RIPK2SYNCI
  • Tyrosine-Protein Kinase RIPK2SYNCI
  • Receptor Interacting Protein 2SYNCI
  • Receptor-Interacting Protein 2SYNCI
Swiss_Prot
  • O43353
DEFINITION
  • Receptor-interacting serine/threonine-protein kinase 2 (540 aa, ~61 kDa) is encoded by the human RIPK2 gene. This protein is involved in protein phosphorylation, apoptosis and inflammation.NCI
DesignNote
  • Receptor-interacting serine/threonine-protein kinase 2 also has tyrosine kinase activity. (UniProt)
  • Receptor-interacting serine/threonine-protein kinase 2 contains 1 CARD domain, activates NF-Kappa B and potentiates apoptosis by activating pro-caspase-1 and pro-caspase-8. RIPK2 binds to BIRC3/c-IAP1, BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5, and TRAF6 and binds to CFLAR/CLARP and CASP1 via their CARD domains. RIPK2 may be a component of the TNFRSF1A and TNRFSF5/CD40 receptor complexes.
code
  • C29872
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