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AttributesValues
rdf:type
rdfs:label
  • Timolol Maleate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Timolol Maleate
UMLS_CUI
  • C0087093
CAS_Registry
  • 26921-17-5
FDA_UNII_Code
  • P8Y54F701R
Contributing_Source
  • FDA
Chemical_Formula
  • C13H24N4O3S.C4H4O4
Legacy_Concept_Name
  • Timolol_Maleate
CHEBI_ID
  • CHEBI:9600
FULL_SYN
  • TIMOLOL MALEATEPTFDAP8Y54F701R
  • Timolol MaleatePTNCI
  • Timolol maleatePTDCP32066
DEFINITION
  • The maleate salt form of timolol, a propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis.NCI
code
  • C29501
is Has_Salt_Form of
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