About: 3'-C-ethynylcytidine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • 3'-C-ethynylcytidine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • 3'-C-ethynylcytidine
UMLS_CUI
  • C0533115
CAS_Registry
  • 180300-43-0
PDQ_Open_Trial_Search_ID
  • 614024
PDQ_Closed_Trial_Search_ID
  • 614024
Legacy_Concept_Name
  • TAS-106
FULL_SYN
  • ECdyABNCI
  • ECydABNCI
  • 3'-C-EthynylcytidinePTDCP50626
  • TAS-106CNNCI
  • 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosineSNNCI
  • 3'-C-ethynylcytidinePTNCI
  • 3'-C-ethynylcytidineSYNCI
DEFINITION
  • A synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. 3'-C-ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis. RNase L is a potent antiviral and antiproliferative endoribonuclease that cleaves singled stranded RNA, causes 28s rRNA fragmentation, and activates Janus Kinase (JAK), a mitochondrial-dependent apoptosis signaling molecule.NCI
code
  • C29475
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