About: Phenylephrine/Phenylpropanolamine/Guaifenesin

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About: Phenylephrine/Phenylpropanolamine/Guaifenesin Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Phenylephrine/Phenylpropanolamine/Guaifenesin
rdfs:subClassOf	Cough and Cold Preparation
Semantic_Type	Pharmacologic Substance
Preferred_Name	Phenylephrine/Phenylpropanolamine/Guaifenesin
UMLS_CUI	C1445789
Legacy_Concept_Name	Phenylephedrine_Phenylpropanolamine_Guaifenesin
FULL_SYN	Phenylephrine/Phenylpropanolamine/GuaifenesinPTNCI
DEFINITION	A combination preparation containing phenylephrine, phenylpropanolamine and guaifenesin with decongestant and expectorant activities. Phenylephrine and phenylpropanolamine, direct-acting sympathicomimetic amines, activate alpha-adrenergic receptors in the nasal mucosa thereby causing vasoconstriction, reduces swelling of nasal mucous membranes and decreasing nasal and sinus congestion. Phenylpropanolamine also releases norepinephrine from its storage sites resulting in the effects already described. Guaifenesin increases respiratory tract mucus secretions and reduces the viscosity of mucus secretion by reducing adhesiveness and surface tension as well as increasing hydration of mucus, thereby increasing the efficiency of removing accumulated secretions from the upper and lower airways and making cough more productive.NCI
code	C29362

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