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AttributesValues
rdf:type
rdfs:label
  • Nitroglycerin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Nitroglycerin
UMLS_CUI
  • C0017887
CAS_Registry
  • 55-63-0
Accepted_Therapeutic_Use_For
  • Anal Fissure and Fistula
FDA_UNII_Code
  • G59M7S0WS3
Contributing_Source
  • FDA
ALT_DEFINITION
  • In medicine, a substance used as a drug to treat certain heart conditions and to widen the openings in blood vessels. Nitroglycerin is being studied as a way to help chemotherapy work better by making tumor cells more sensitive to the drugs. It is a type of vasodilator.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 587505
PDQ_Closed_Trial_Search_ID
  • 587505
Chemical_Formula
  • C3H5N3O9
Legacy_Concept_Name
  • Nitroglycerin
CHEBI_ID
  • CHEBI:28787
FULL_SYN
  • NITROGLYCERINPTFDAG59M7S0WS3
  • NitroglycerinPTNCI
  • nitroglycerinPTNCI-GLOSSCDR0000626334
  • RectivBRNCI
DEFINITION
  • An organic nitrate with vasodilator activity. Nitroglycerin is converted into nitric oxide (NO) in smooth muscle and activates guanylyl cyclase, thereby increasing cGMP concentration, and resulting in smooth muscle relaxation. Dilatation of the veins results in decreased venous return to the heart, thereby decreasing left ventricular volume (reduced preload) and decreasing myocardial oxygen requirements. Arteriolar relaxation reduces arteriolar resistance (reduced afterload), thereby decreasing myocardial oxygen demands. In addition, nitroglycerine causes coronary artery dilatation, thereby improving myocardial blood distribution.NCI
code
  • C29294
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