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AttributesValues
rdf:type
rdfs:label
  • Nifedipine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Nifedipine
UMLS_CUI
  • C0028066
CAS_Registry
  • 21829-25-4
FDA_UNII_Code
  • I9ZF7L6G2L
Contributing_Source
  • FDA
Chemical_Formula
  • C17H18N2O6
Legacy_Concept_Name
  • Nifedipine
CHEBI_ID
  • CHEBI:7565
FULL_SYN
  • NifedipinePTDCP30189
  • AdalatBRNCI
  • NIFEDIPINEPTFDAI9ZF7L6G2L
  • ProcardiaBRNCI
  • NifedipinePTNCI
DEFINITION
  • A dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)NCI
code
  • C29290
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