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AttributesValues
rdf:type
rdfs:label
  • Nadolol
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Nadolol
UMLS_CUI
  • C0027302
CAS_Registry
  • 42200-33-9
FDA_UNII_Code
  • FEN504330V
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 659002
PDQ_Closed_Trial_Search_ID
  • 659002
Legacy_Concept_Name
  • Nadolol
CHEBI_ID
  • CHEBI:7444
FULL_SYN
  • NADOLOLPTFDAFEN504330V
  • CorgardBRNCI
  • NadololPTNCI
  • NadololPTDCP32068
DEFINITION
  • A non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Nadolol competitively blocks beta-1 adrenergic receptors located in the heart and vascular smooth muscle, inhibiting the activities of the catecholamines epinephrine and norepinephrine and producing negative inotropic and chronotropic effects. This agent exhibits antiarrhythmic activity via the impairment of atrioventricular (AV) node conduction and a corresponding reduction in sinus rate. In the kidney, inhibition of the beta-2 receptor within the juxtaglomerular apparatus results in the inhibition of renin production and a subsequent reduction in angiotensin II and aldosterone levels, thus inhibiting angiotensin II-dependent vasoconstriction and aldosterone-dependent water retention.NCI
code
  • C29280
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