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AttributesValues
rdf:type
rdfs:label
  • Milk Thistle
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Milk Thistle
UMLS_CUI
  • C0937640
ALT_DEFINITION
  • A plant that has been used in some cultures to treat certain medical problems, including stomach, liver, and gallbladder disorders. The active extract of milk thistle seeds is called silymarin. It is being studied in the prevention of liver damage caused by some cancer treatments.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 459958
PDQ_Closed_Trial_Search_ID
  • 459958
Legacy_Concept_Name
  • Milk_Thistle
FULL_SYN
  • Milk ThistlePTNCI
  • milk thistlePTNCI-GLOSSCDR0000305993
DEFINITION
  • A substance derived from any of several Old World coarse prickly-leaved shrubs and subshrubs including the plant Silybum marianum. Milk thistle's active chemical component is silymarin, which is a combination of flavonoids such as silibinin, dehydrosilibinin, silychristin and silydianin. These compounds are antioxidants and may alter the membrane structure of the liver cell, thereby blocking the absorption of toxins; they may also stimulate the production of new liver cells. In addition, milk thistle may increase cellular adenosine triphosphate (ATP) levels, exhibiting dose-dependent cardiac myocyte cytoprotection against doxorubicin. The silibinin component of milk thistle has been shown to inhibit growth factor receptor-mediated mitogenic and cell survival signaling, thereby inhibiting tumor growth. (NCI04)NCI
code
  • C29261
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