About: Retroviral Vector MFGS-MOv18-gamma     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Retroviral Vector MFGS-MOv18-gamma
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Retroviral Vector MFGS-MOv18-gamma
NSC_Code
  • 693240
UMLS_CUI
  • C1514927
Legacy_Concept_Name
  • Retroviral_Vector_MFGS-MOv18-gamma
FULL_SYN
  • Retroviral Vector MFGS-MOv18-gammaPTNCI
  • MFG-S MOv18-gamma-IN Retroviral VectorSYNCI
DEFINITION
  • A recombinant retrovirus containing the modified murine retroviral vector MFG-S encoding a chimeric construct, MOv18-gamma. MOv18 is a murine monoclonal antibody developed against epitope of human folate binding protein, which is overexpressed on more than 90% of non-mucinous epithelial ovarian neoplasms. The chimeric construct (MOv18-gamma) encodes the variable region of MOv18 antibody, and the gamma chain of human T-cell receptor. This virion might be used to transduce autologous T lymphocytes, and reintroduced back to the patient after expansion ex vivo to invoke specific immune response against ovarian cancer cells.NCI
code
  • C29192
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