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AttributesValues
rdf:type
rdfs:label
  • Loratadine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Loratadine
NSC_Code
  • 721075
UMLS_CUI
  • C0065180
CAS_Registry
  • 79794-75-5
FDA_UNII_Code
  • 7AJO3BO7QN
Contributing_Source
  • FDA
Chemical_Formula
  • C22H23ClN2O2
Legacy_Concept_Name
  • Loratadine
FULL_SYN
  • 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, Ethyl EsterSNNCI
  • LORATADINEPTFDA7AJO3BO7QN
  • ClaritinBRNCI
  • LoratadinePTNCI
DEFINITION
  • A piperidine histamine H1-receptor antagonist with anti-allergic properties and without sedative effects. Loratadine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. Loratadine does not cross the blood-brain barrier and does not cause central nervous system effects.NCI
code
  • C29162
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