About: Labetalol

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Labetalol
rdfs:subClassOf	Adrenergic Antagonist
Has_Salt_Form	LABETALOL HYDROCHLORIDE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Labetalol
UMLS_CUI	C0022860
CAS_Registry	36894-69-6
FDA_UNII_Code	R5H8897N95
Contributing_Source	FDA
Chemical_Formula	C19H24N2O3
Legacy_Concept_Name	Labetalol
CHEBI_ID	CHEBI:6343
FULL_SYN	LabetalolPTDCP30283 LABETALOLPTFDAR5H8897N95 LabetalolPTNCI
DEFINITION	A third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects.NCI
code	C29146
is Has_Free_Acid_Or_Base_Form of	LABETALOL HYDROCHLORIDE

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