About: Imexon     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Imexon
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Imexon
NSC_Code
  • 714597
UMLS_CUI
  • C0097147
CAS_Registry
  • 59643-91-3
FDA_UNII_Code
  • 8F63U28T2V
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of some types of cancer, including pancreatic, lung, breast, prostate, melanoma, and multiple myeloma. It belongs to the family of drugs called cyanoaziridine derivatives.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 468469
PDQ_Closed_Trial_Search_ID
  • 468469
Chemical_Formula
  • C4H5N3O
Legacy_Concept_Name
  • Imexon
FULL_SYN
  • AmplimexonPTNCI-GLOSSCDR0000513068
  • IMEXONPTFDA8F63U28T2V
  • imexonPTNCI-GLOSSCDR0000471783
  • ImexonPTNCI
  • 4-imino-1,3-diazabicyclo[3,1,0]-hexan-2-oneSNNCI
  • AmplimexonBRNCI
DEFINITION
  • A 2-cyanoaziridine derivative with antitumor activity in multiple myeloma. Although its mechanism of action is not clearly known, imexon may induce apoptosis via a pathway involving cleaved caspase-3, caspase-9, and/or caspase-8. Other cytotoxic mechanisms of action of this agent may involve thiol depletion, generation of reactive oxygen species (ROS), and decreases in the mitochondrial membrane potential. (NCI04)NCI
code
  • C29115
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software