About: Fexofenadine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Fexofenadine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fexofenadine Hydrochloride
NSC_Code
  • 169453
  • 78248
UMLS_CUI
  • C0771752
CAS_Registry
  • 138452-21-8
  • 153439-40-8
FDA_UNII_Code
  • 2S068B75ZU
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat certain allergy symptoms. It blocks a chemical released during an allergic response that causes itching, sneezing, runny nose, wheezing, and watery eyes. It is a type of antihistamine.NCI-GLOSS
Chemical_Formula
  • C32H39NO4.HCl
Legacy_Concept_Name
  • Fexofenadine_Hydrochloride
FULL_SYN
  • Fexofenadine HydrochloridePTNCI
  • Fexofenadine HClSYNCI
  • AllegraPTNCI-GLOSSCDR0000589405
  • AllegraBRNCI
  • FEXOFENADINE HYDROCHLORIDEPTFDA2S068B75ZU
DEFINITION
  • The hydrochloride salt form of fexofenadine, a carboxylated metabolic derivative of terfenadine and third generation selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Fexofenadine competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently histamine binding and activity as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandin and leukotriene precursors, is blocked, thereby preventing the triggering of pro-inflammatory pathways.NCI
code
  • C29050
is Has_Salt_Form of
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