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AttributesValues
rdf:type
rdfs:label
  • Digoxin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Digoxin
NSC_Code
  • 95100
UMLS_CUI
  • C0012265
CAS_Registry
  • 20830-75-5
FDA_UNII_Code
  • 73K4184T59
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat irregular heartbeat and some types of heart failure. It is also being studied in the treatment of some types of cancer. Digoxin helps the heart work normally by controlling the amount of calcium that goes into the heart muscle. It also may kill cancer cells and make them more sensitive to anticancer drugs. It is a type of cardiac glycoside.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 485249
PDQ_Closed_Trial_Search_ID
  • 485249
Chemical_Formula
  • C41H64O14
Legacy_Concept_Name
  • Digoxin
CHEBI_ID
  • CHEBI:4551
FULL_SYN
  • CardiogoxinBRNCI
  • 12beta-HydroxydigitoxinSYNCI
  • DIGOXINPTFDA73K4184T59
  • Digoxigenin-tridigitoxosidSYNCI
  • 3beta,12beta,14-Trihydroxy-5beta,14beta-card-20(22)-enolid-3-tridigitoxosidSNNCI
  • LanoxinPTNCI-GLOSSCDR0000593103
  • digoxinPTNCI-GLOSSCDR0000476342
  • DigoxinPTNCI
  • LanoxinBRNCI
DEFINITION
  • A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. (NCI04)NCI
code
  • C28990
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