About: Atorvastatin Calcium

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Attributes	Values
rdf:type	Class
rdfs:label	Atorvastatin Calcium
rdfs:subClassOf	HMG-CoA Reductase Inhibitor nodeID://b647504 nodeID://b647505 nodeID://b647506 nodeID://b647507 nodeID://b647508 nodeID://b647509 nodeID://b647510 nodeID://b647511
Has_Free_Acid_Or_Base_Form	ATORVASTATIN
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Atorvastatin Calcium
UMLS_CUI	C0286650
CAS_Registry	134523-03-8 344423-98-9
FDA_UNII_Code	48A5M73Z4Q
Contributing_Source	FDA
ALT_DEFINITION	A drug used to lower the amount of cholesterol in the blood and to prevent stroke, heart attack, and angina (chest pain). It is also being studied in the prevention and treatment of some types of cancer and other conditions. Atorvastatin calcium blocks an enzyme that helps make cholesterol in the body. It also causes an increase in the breakdown of cholesterol. It is a type of HMG-CoA reductase inhibitor and a type of statin.NCI-GLOSS
PDQ_Open_Trial_Search_ID	460239
PDQ_Closed_Trial_Search_ID	460239
Chemical_Formula	2C33H34FN2O5.Ca.3H2O
Legacy_Concept_Name	Atorvastatin
CHEBI_ID	CHEBI:2911
FULL_SYN	ATORVASTATIN CALCIUMPTFDA48A5M73Z4Q atorvastatin calciumPTNCI-GLOSSCDR0000535469 Atorvastatin CalciumPTDCP09486 CI-981CNNCI LipitorPTNCI-GLOSSCDR0000535468 LipitorBRNCI Atorvastatin CalciumPTNCI
DEFINITION	The calcium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent increases the number of LDL receptors on hepatic cell surfaces, enhancing the uptake and catabolism of LDL and reducing LDL production and the number of LDL particles, and lowers plasma cholesterol and lipoprotein levels. Like other statins, atorvastatin may also display direct antineoplastic activity, possibly by inhibiting farnesylation and geranylgeranylation of proteins such as small GTP-binding proteins, which may result in the arrest of cells in the G1 phase of the cell cycle. This agent may also sensitize tumor cells to cyctostatic drugs, possibly through the mTOR-dependent inhibition of Akt phosphorylation.NCI
code	C28837
is Has_Salt_Form of	ATORVASTATIN

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