About: Amantadine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amantadine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Amantadine Hydrochloride
NSC_Code
  • 83653
UMLS_CUI
  • C0723562
CAS_Registry
  • 665-66-7
Accepted_Therapeutic_Use_For
  • Parkinson disease; infections caused by influenza A virus
FDA_UNII_Code
  • M6Q1EO9TD0
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat infections caused by the influenza A virus. It blocks the ability of the virus to infect cells and to make more virus particles. It is also used to treat the symptoms of Parkinson disease. Amantidine hydrochloride is a type of antiviral agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 471831
PDQ_Closed_Trial_Search_ID
  • 471831
Chemical_Formula
  • C10H17N.ClH
Legacy_Concept_Name
  • Amantadine_Hydrochloride
CHEBI_ID
  • CHEBI:2619
FULL_SYN
  • amantadine hydrochloridePTNCI-GLOSSCDR0000644726
  • Amantadine HydrochloridePTNCI
  • Amantadine HClSYNCI
  • AMANTADINE HYDROCHLORIDEPTFDAM6Q1EO9TD0
  • SymmetrelBRNCI
DEFINITION
  • The hydrochloride salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.NCI
code
  • C28818
is Has_Salt_Form of
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