About: Alprostadil     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Alprostadil
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Alprostadil
NSC_Code
  • 165559
UMLS_CUI
  • C0592016
CAS_Registry
  • 745-65-3
Accepted_Therapeutic_Use_For
  • Erectile dysfunction; Patent ductus arteriosus
In_Clinical_Trial_For
  • Prostate cancer-associated erectile dysfunction
FDA_UNII_Code
  • F5TD010360
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat impotence (inability to have an erection) and is being studied in the treatment of sexual problems in men who have had surgery for prostate cancer. It is a type of vasodilator.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 360459
PDQ_Closed_Trial_Search_ID
  • 360459
Chemical_Formula
  • C20H34O5
Legacy_Concept_Name
  • Alprostadil
CHEBI_ID
  • CHEBI:15544
FULL_SYN
  • AlprostadilPTNCI
  • (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic AcidPTDCP05594
  • PGE1PTNCI-GLOSSCDR0000613199
  • alprostadilPTNCI-GLOSSCDR0000613198
  • PGE1ABNCI
  • MUSEBRNCI
  • Prostaglandin E1SYNCI
  • (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic AcidSNNCI
  • ALPROSTADILPTFDAF5TD010360
  • CaverjectBRNCI
  • prostaglandin E1PTNCI-GLOSSCDR0000613197
DEFINITION
  • The naturally occuring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP.NCI
code
  • C28816
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