About: CDC7L1 Kinase Complex

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About: CDC7L1 Kinase Complex Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	CDC7L1 Kinase Complex
rdfs:subClassOf	Protein or Riboprotein Complex nodeID://b653796
Semantic_Type	Enzyme
Preferred_Name	CDC7L1 Kinase Complex
UMLS_CUI	C1332726
Legacy_Concept_Name	CDC7L1_Kinase_Complex
FULL_SYN	CDC7L1 Kinase ComplexPTNCI
DEFINITION	The G1/S transition in eukaryotic cells is strictly regulated so that DNA replication occurs only once during S phase. The CDC7L1 kinase complex may trigger S phase by directly activating the replication initiation complexes assembled at the origins. Phosphorylation of MCM2 and MCM3 in the MCM complex by the CDC7L1 kinase complex converts the inactive MCM complex into an active helicase. Activator of S Phase Kinase, encoded by the ASK gene, is a cyclin-like regulatory subunit of the CDC7L1 kinase complex. This protein is the major activator of CDC7L1. ASK plays a pivotal role in the G1/S transition in mammalian cells and its function is essential for entry into S phase. ASK interacts with CDC7L1 and stimulates the kinase activity of CDC7L1. CDC7L1-dependent kinase activity reflects the ASK protein level, significantly increasing in cells in S phase, and ASK protein is extensively phosphorylated during S phase, presumably by CDC7L1.NCI
code	C28672
is someValuesFrom of	nodeID://b643859 nodeID://b653802

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