About: Asparaginase

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Attributes	Values
rdf:type	Class
rdfs:label	Asparaginase
rdfs:subClassOf	Enzyme Replacement or Supplement Agent
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Enzyme Pharmacologic Substance
Preferred_Name	Asparaginase
NSC_Code	109229
UMLS_CUI	C0003993
CAS_Registry	9015-68-3
Accepted_Therapeutic_Use_For	Acute lymphocytic leukemia; Acute non-lymphocytic leukemia
In_Clinical_Trial_For	Acute lymphoblastic leukemia; Acute myeloid leukemia; Lymphoblastic non-Hodgkins lymphoma; Myelodysplastic syndromes
FDA_UNII_Code	G4FQ3CKY5R
Contributing_Source	FDA
ALT_DEFINITION	A drug that is used to treat acute lymphoblastic leukemia (ALL) and is being studied in the treatment of some other types of cancer. It is an enzyme taken from the bacterium Escherichia coli (E. coli). It breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41146
PDQ_Closed_Trial_Search_ID	41146
Legacy_Concept_Name	Asparaginase
FULL_SYN	Re-82-TAD-15CNNCI AsparaginaseSYDTPNSC0109229 AsparaginasePTNCI L-Asparagine amidohydrolaseSYDTPNSC0109229 L-AsparaginaseSYNCI ElsparSYDTPNSC0174950 asparaginasePTNCI-GLOSSCDR0000045339 L-AsparaginaseSYDTPNSC0174950 Asparaginase IISYNCI LeunaseSYDTPNSC0174950 ElsparPTNCI-GLOSSCDR0000601031 L-Asparagine AmidohydrolaseSYNCI ASP-1SYNCI L-ASPABNCI L-AsnaseSYDTPNSC0174950 LeucogenSYDTPNSC0109229 MK-965CNNCI L-asparaginasePTNCI-GLOSSCDR0000601030 SerasaFBNCI LasparFBNCI ElsparBRNCI Lcf-ASPABNCI LeunaseFBNCI ParonalFBNCI ColaspaseSYDTPNSC0174950 KidrolaseSYDTPNSC0109229 Asparaginase-E.ColiSYNCI L-AsnaseBRNCI LeucogenFBNCI KidrolaseFBNCI ColaspaseSYNCI ASPARAGINASEPTFDAG4FQ3CKY5R
DEFINITION	An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations. Asparagine is critical to protein synthesis in leukemic cells; some leukemic cells cannot synthesize this amino acid de novo due to the absent or deficient expression of the enzyme asparagine synthase. The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity.NCI
code	C286
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