About: Recombinant Adenovirus-hIFN-beta     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Adenovirus-hIFN-beta
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Adenovirus-hIFN-beta
UMLS_CUI
  • C1527241
In_Clinical_Trial_For
  • Recurrent or Progressive Glioblastoma Multiforme and Grade III or IV Gliomas.
ALT_DEFINITION
  • A gene therapy agent that is being studied in the treatment of cancer. It belongs to the family of drugs called biological response modifiers.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38609
PDQ_Closed_Trial_Search_ID
  • 38609
Legacy_Concept_Name
  • Recombinant_Adenovirus-hIFN-beta
FULL_SYN
  • Ad-hIFN-betaSYNCI
  • BG00001PTNCI-GLOSSCDR0000340925
  • BG00001CNNCI
  • Recombinant Adenovirus-hIFN-betaPTNCI
DEFINITION
  • A recombinant replication-defective adenovirus which encodes the gene for the cytokine human interferon-beta (IFN-beta). Once inserted into and replicating in host tumor cells, recombinant adenovirus-hIFN-beta expresses human IFN-beta, which may stimulate an antiproliferative natural killer (NK) cell response against tumor cells and induce caspase-mediated tumor cell apoptosis. (NCI04)NCI
code
  • C28550
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