About: Nitric Oxide Synthetase     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Nitric Oxide Synthetase
rdfs:subClassOf
Semantic_Type
  • Enzyme
Preferred_Name
  • Nitric Oxide Synthetase
UMLS_CUI
  • C0132555
Legacy_Concept_Name
  • Nitric_Oxide_Synthetase
FULL_SYN
  • NO SynthaseSYNCI
  • EC 1.14.13.39SYNCI
  • Nitric Oxide SynthetasePTNCI
  • NADPH-DiaphoraseSYNCI
  • Nitric Oxide SynthaseSYNCI
  • Nitric-Oxide SynthaseSYNCI
DEFINITION
  • Expressed in various cell types, Nitric Oxide Synthases (NOS Family) are constitutive or inducible calcium/calmodulin stimulated homodimers stabilized by BH4 that bind FAD and FMN cofactors, generally contain a flavodoxin-like domain, and synthesize reactive free radical nitric oxide messenger from L-arginine. NO can act as a neurotransmitter and has antimicrobial and antitumoral activities in macrophages. IL12 requires NOS to stimulate tyrosine-phosphorylation of STAT4 by TYK2 in NK cytotoxicity. Vascular NO (endothelia) inhibits muscle contraction through a cGMP pathway, inhibits platelet aggregation, and mediates VEGF-induced angiogenesis. Endothelial AKT phosphorylates and enhances NOS activity. Potentially influencing energy balance, NO can trigger cGMP-dependent mitochondrial biogenesis mediated by induction of the master regulator PPARGC1. (NCI)NCI
code
  • C28511
is rdf:first of
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