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AttributesValues
rdf:type
rdfs:label
  • Growth Hormone Releasing Hormone
equivalentClass
OMIM_Number
  • 139190
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Hormone
Preferred_Name
  • Growth Hormone Releasing Hormone
UMLS_CUI
  • C0037668
ALT_DEFINITION
  • A polypeptide hormone produced in the HYPOTHALAMUS, and other tissues and organs. It inhibits the release of growth hormone (SOMATOTROPIN), and also modulates important physiological functions of the kidney, pancreas, and gastrointestinal tract. Somatostatin receptors are widely expressed throughout the body. Somatostatin also acts as a neurotransmitter in the central and peripheral nervous systems.MSH2002_06_01
Legacy_Concept_Name
  • Growth_Hormone-Releasing_Hormone
FULL_SYN
  • Growth Hormone Releasing HormonePTNCI
  • Growth Hormone-Releasing HormoneSYNCI
  • SomatocrininSYNCI
  • SomatoliberinSYNCI
  • GHRHSYNCI
Swiss_Prot
  • P01286
DEFINITION
  • This protein belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in the gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. (from RefSeq)NCI
code
  • C28419
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