About: Paclitaxel PPE Microspheres     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Paclitaxel PPE Microspheres
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Paclitaxel PPE Microspheres
NSC_Code
  • 715074
UMLS_CUI
  • C1518843
Legacy_Concept_Name
  • Paclitaxel_PPE_Microspheres
FULL_SYN
  • Paclitaxel Biopolymer FormulationSYNCI
  • Paclitaxel PPE MicrospheresPTNCI
  • Paclimer Microspheres (Polilactofate/Paclitaxel)SYNCI
  • Paclimer MicrospheresBRNCI
DEFINITION
  • A paclitaxel formulation containing paclitaxel incorporated in biodegradable polyphosphoester (PPE) polymer form with potential antineoplastic activity. Upon intraperitoneal delivery, paclitaxel PPE microspheres slowly and continuously dissolve and deliver paclitaxel to the tumor site, where it binds to tubulin and inhibits the dynamics of disassembly-assembly of microtubules. As a result, this formulation induces cell cycle arrest and leads to cell death.NCI
code
  • C2785
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