About: Anti-Thymocyte Globulin

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Attributes	Values
rdf:type	Class
rdfs:label	Anti-Thymocyte Globulin
rdfs:subClassOf	IMMUNE SUPPRESSANTS
Semantic_Type	Amino Acid, Peptide, or Protein Immunologic Factor
Preferred_Name	Anti-Thymocyte Globulin
UMLS_CUI	C0305055
Accepted_Therapeutic_Use_For	Heart and renal transplantation rejection, prophylaxis
In_Clinical_Trial_For	Lysosomal storage diseases; Mucopolysaccharidosis I; Myelodysplastic syndrome; Myeloproliferative disease; Peroxisomal disorders; Rheumatoid arthritis; Sickle cell anemia; Thalassemia Aplastic anemia; Autoimmune diseases; Benign congenital bone marrow failure disorders; Breast cancer; Crohns disease; Graft versus Host Disease; Hematologic cancer; Kidney transplantation;
ALT_DEFINITION	Serum from blood that contains antibodies that bind to human T cells. Antithymocyte globulin is given to a patient before a stem cell transplant to kill T cells and lower the risk of graft-versus-host disease (GVHD). It is also used to treat GVHD and after a kidney transplant to help keep the body from rejecting the kidney.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39337
PDQ_Closed_Trial_Search_ID	39337
Legacy_Concept_Name	Antithymocyte_Globulin
FULL_SYN	Antithymocyte GlobulinSYNCI Anti-Thymocyte GlobulinPTNCI ThymoglobulinBRNCI ATGABNCI ATSABNCI ATGAMBRNCI Antithymocyte SerumSYNCI antithymocyte globulinPTNCI-GLOSSCDR0000045600
DEFINITION	A purified gamma immunoglobulin (IgG) with immunosuppressive activity. Obtained from animals that have been immunized with human thymocytes, antithymocyte globulin (ATG) specifically recognizes and destroys T lymphocytes. Although not completely understood, the mechanism of action appears to involve T lymphocyte clearance from the circulation and modulation of T lymphocyte activity. Administering ATG with chemotherapy prior to stem cell transplantation may reduce the risk of graft-versus-host (GVH) disease.NCI
code	C278
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