About: Rhodacyanine Analog MKT-077     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Rhodacyanine Analog MKT-077
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Rhodacyanine Analog MKT-077
UMLS_CUI
  • C0386288
CAS_Registry
  • 147366-41-4
Legacy_Concept_Name
  • Rhodacyanine
FULL_SYN
  • 1-Ethyl-2-[[-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]pyridinium ChloridePTDCP50274
  • Rhodacyanine Analog MKT-077PTNCI
  • FJ 776CNNCI
  • MKT-077SYNCI
  • 1-ethyl-2-[3-ethyl-5-(3-methylbenzothiazolin-2-yliden)-4-oxothiazolidin-2-ylidenemethyl] pyridinium chlorideSNNCI
DEFINITION
  • A synthetic heterocyclic pyridinium compound. MKT-077 is a water soluble lipophilic cationic molecule and an analog of rhodacyanine dye, which partitions into tumor cell mitochondria where it is thought to act as a metabolic poison, leading to G1 arrest and apoptosis. This agent also shows selective cytotoxicity to cancer cells mediated by its binding to the hsp70 family protein mot-2 and reactivation of tumor suppressor p53 function.NCI
code
  • C2731
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