About: Therapeutic Immune Globulin

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Attributes	Values
rdf:type	Class
rdfs:label	Therapeutic Immune Globulin
rdfs:subClassOf	Immunomodulating Agent
Semantic_Type	Amino Acid, Peptide, or Protein Immunologic Factor
Preferred_Name	Therapeutic Immune Globulin
NSC_Code	621996
UMLS_CUI	C0085297
PDQ_Open_Trial_Search_ID	40109
PDQ_Closed_Trial_Search_ID	40109
Legacy_Concept_Name	Therapeutic_Immune_Globulin
FULL_SYN	Polygam S/DBRNCI PanglobulinBRNCI Gammagard S/DBRNCI SandoglobulinBRNCI Venoglobulin-IBRNCI Venoglobulin-SBRNCI Therapeutic ImmunoglobulinSYNCI IgIVABNCI Therapeutic Immune GlobulinPTNCI Immune Globulin IntravenousSYNCI BayGamBRNCI Immune Globulin IVSYNCI Gammar-PBRNCI WinRho SDFBRNCI Iveegam ENBRNCI Gamimune NBRNCI
DEFINITION	A preparation of plasma proteins derived from the pooled plasma of adult donors. Largely comprised of IgG antibodies, therapeutic immune globulin provides passive immunization by increasing the recipient's serum levels of circulating antibodies. IgG antibodies have multiple functions, including binding to and neutralizing bacterial toxins; opsonization of pathogens; activation of complement; and suppression of pathogenic cytokines and phagocytes through binding to CD5, interleukin-1a (IL-1a), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and T-cell receptors. Therapeutic immune globulin may diminish pathogenic mechanisms in some autoimmune diseases by binding to and inhibiting the activity of autoantibodies. (NCI04)NCI
code	C2701
is rdfs:subClassOf of	Therapeutic Hepaptitic C Immune Globulin Lapine T-Lymphocyte Immune Globulin High-titer RSV Immune Globulin RI-001 Equine Thymocyte Immune Globulin Human Botulinum Neurotoxin A/B Immune Globulin Human Cytomegalovirus Immune Globulin Human Hepatitis B Virus Immune Globulin Human Rabies Virus Immune Globulin RHO (D) IMMUNE GLOBULIN,HUMAN Human Vaccinia Virus Immune Globulin MICRURUS FULVIUS ANTIVENIN
is someValuesFrom of	nodeID://b682280

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