About: Paclitaxel Albumin-Stabilized Nanoparticle Formulation     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Paclitaxel Albumin-Stabilized Nanoparticle Formulation
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Paclitaxel Albumin-Stabilized Nanoparticle Formulation
NSC_Code
  • 736631
UMLS_CUI
  • C1527223
Accepted_Therapeutic_Use_For
  • Metastatic breast cancer
In_Clinical_Trial_For
  • Metastatic Breast Cancer, Locally Advanced or Metastatic Solid Tumor
ALT_DEFINITION
  • A drug used to treat breast cancer that has spread or that has come back within 6 months after chemotherapy. It is also being studied in the treatment of newly diagnosed breast cancer and other types of cancer. ABI-007 is a type of mitotic inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38690
PDQ_Closed_Trial_Search_ID
  • 38690
Legacy_Concept_Name
  • ABI-007
FULL_SYN
  • Albumin-Stabilized Nanoparticle PaclitaxelSYNCI
  • protein-bound paclitaxelSYNCI-GLOSSCDR0000507751
  • Nanoparticle PaclitaxelSYNCI
  • Albumin-bound PaclitaxelSYNCI
  • Paclitaxel Albumin-Stabilized Nanoparticle FormulationPTNCI
  • nab-paclitaxelSYNCI
  • Nanoparticle Albumin-bound PaclitaxelSYNCI
  • ABI-007SYNCI-GLOSSCDR0000367434
  • ABI 007CNNCI
  • ABI-007CNNCI
  • AbraxaneSYNCI-GLOSSCDR0000488416
  • AbraxaneBRNCI
  • paclitaxel albumin-stabilized nanoparticle formulationSYNCI-GLOSSCDR0000507600
  • nanoparticle paclitaxelSYNCI-GLOSSCDR0000507601
DEFINITION
  • A Cremophor EL-free, albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity. Paclitaxel binds to and stabilizes microtubules, preventing their depolymerization and so inhibiting cellular motility, mitosis, and replication. This formulation solubilizes paclitaxel without the use of the solvent Cremophor, thereby permitting the administration of larger doses of paclitaxel while avoiding the toxic effects associated with Cremophor.NCI
code
  • C2688
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software