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AttributesValues
rdf:type
rdfs:label
  • Lenalidomide
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Lenalidomide
PubMedID_Primary_Reference
  • 16085014
NSC_Code
  • 703813
UMLS_CUI
  • C1144149
CAS_Registry
  • 191732-72-6
Accepted_Therapeutic_Use_For
  • Transfusion-dependent anemia due to low- or intermediate-1 risk myelodysplastic syndrome; multiple myeloma
In_Clinical_Trial_For
  • Recurrent high-grade gliomas; progressive or relapsed metastatic malignant melanoma; refractory solid tumors and /or lymphoma.
  • Myelodysplastic syndromes; glioma; melanoma; solid tumors; leukemia; lymphoma; small intestine cancer
FDA_UNII_Code
  • F0P408N6V4
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is similar to thalidomide, and is used to treat multiple myeloma and certain types of anemia. It is also being studied in the treatment of other types of cancer. Lenalidomide belongs to the family of drugs called angiogenesis inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38564
PDQ_Closed_Trial_Search_ID
  • 38564
Chemical_Formula
  • C13H13N3O3
Legacy_Concept_Name
  • CC-5013
CHEBI_ID
  • CHEBI:63791
FULL_SYN
  • LenalidomidePTNCI
  • lenalidomidePTNCI-GLOSSCDR0000393761
  • 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dioneSNNCI
  • CC-5013PTNCI-GLOSSCDR0000045081
  • CC5013CNNCI
  • CC-5013CNNCI
  • CDC 501CNNCI
  • RevlimidPTNCI-GLOSSCDR0000507521
  • RevlimidBRNCI
  • LENALIDOMIDEPTFDAF0P408N6V4
DEFINITION
  • A thalidomide analog with potential antineoplastic activity. Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells.NCI
code
  • C2668
is someValuesFrom of
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