About: TAK1 Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • TAK1 Protein
equivalentClass
OMIM_Number
  • 602614
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • TAK1 Protein
UMLS_CUI
  • C1435846
Legacy_Concept_Name
  • TAK1_Protein
FULL_SYN
  • MAP3K7SYNCI
  • TAK1 ProteinPTNCI
  • TGF-Beta Activated Kinase 1SYNCI
  • Mitogen-Activated Protein Kinase Kinase Kinase 7SYNCI
  • TGF1A-DSYNCI
  • Transforming Growth Factor-Beta-Activated Kinase 1SYNCI
Swiss_Prot
  • O43318
DEFINITION
  • Encoded by MAP3K7 Gene (MAP3K Family), ubiquitous TAK1 Protein isoforms A, B (606-aa, 67.2-kD), C, and D regulate transcription and apoptosis by mediating TGFB/BMP, IL-1, and stress signaling. Isoforms A, C, and D lack 1-2 coding segments compared to B. C and D frameshifts yield shorter C-termini (may affect TAB2 interaction). Human and mouse TAK1 are 99% identical. The TAK1 N-terminus interacts with TAB1 and contains ATP-binding and kinase domains. With TAB1 and TAB2, TRIKA2-mediated (TRAF6/TRIKA1) ubiquitinated TAK1 phosphorylates IKKB, MAP2K3, MAP2K4, and MAP2K6, which stimulate JNK1 and SAPK2. TAK1 induces NIK-independent IKBA and IKBB degradation and NFKB p50/p65 nuclear translocation. (from LocusLink, Swiss-Prot, OMIM, and NCI)NCI
code
  • C26488
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