About: Methyl-5-Aminolevulinate Hydrochloride Cream     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Methyl-5-Aminolevulinate Hydrochloride Cream
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Methyl-5-Aminolevulinate Hydrochloride Cream
UMLS_CUI
  • C2713112
In_Clinical_Trial_For
  • Primary Nodular Basal Cell Carcinoma of the Skin and Actinic Keratosis.
ALT_DEFINITION
  • A drug used in photodynamic therapy; it is absorbed by tumor cells and, when exposed to light, becomes active and kills the cancer cells.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38410
PDQ_Closed_Trial_Search_ID
  • 38410
Legacy_Concept_Name
  • Methyl-5-Aminolevulinate
FULL_SYN
  • Methyl Aminolevulinate Hydrochloride CreamSYNCI
  • methyl-5-aminolevulinatePTNCI-GLOSSCDR0000045042
  • Methyl-5-Aminolevulinate Hydrochloride CreamPTNCI
  • MetvixFBNCI
  • MetvixiaBRNCI
DEFINITION
  • A topical cream formulation containing the hydrochloride salt of methyl-5-aminolevulinate, a lipophilic methyl ester of 5-aminolevulinic acid, with photosensitizer prodrug activity. Upon topical administration, methyl-5-aminolevulinate in the cream is selectively absorbed by tumor cells where it is converted to the photosensitizer protoporphyrin IX (PpIX). Upon photoirradiation, PpIX is activated and transfers energy to oxygen, generating singlet oxygen and superoxide and hydroxyl radicals, which may result in free-radical-mediated DNA damage and cell death.NCI
code
  • C2647
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