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AttributesValues
rdf:type
rdfs:label
  • HPPH
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • HPPH
UMLS_CUI
  • C0248392
CAS_Registry
  • 149402-51-7
In_Clinical_Trial_For
  • Basal Cell Skin Cancer; Obstructive Esophageal Tumors; Early Stage or Centrally Obstructing Non-small Cell Lung Cancer; Locally Reoccurring Breast Cancer on the Chest Wall.
ALT_DEFINITION
  • A drug that is used in photodynamic therapy that is absorbed by tumor cells; when exposed to light, it becomes active and kills the cancer cells.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38335
PDQ_Closed_Trial_Search_ID
  • 38335
Legacy_Concept_Name
  • HPPH
FULL_SYN
  • HPPHPTNCI-GLOSSCDR0000045031
  • HPPHPTNCI
  • 2-(1-Hexyloxyethyl)-2-Devinyl Pyropheophorbide-aSNNCI
  • PhotochlorBRNCI
DEFINITION
  • A lipophilic, second-generation, chlorin-based photosensitizer. Upon intravenous administration, HPPH selectively accumulates in the cytoplasm of cancer or pre-cancerous cells. When laser light is applied, a photodynamic reaction between HPPH and oxygen occurs, resulting in the production of cytotoxic free radicals and singlet oxygen and free radical-mediated cell death. Compared to the first-generation photosensitizer porfimer sodium, HPPH shows improved pharmacokinetic properties and causes only mild skin photosensitivity which declines rapidly within a few days after administration.NCI
code
  • C2636
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