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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Digitoxin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Digitoxin
NSC_Code
  • 7529
UMLS_CUI
  • C0012258
CAS_Registry
  • 71-63-6
Accepted_Therapeutic_Use_For
  • Atrial Fibrillation; Atrial Flutter; Congestive Heart Failure; Supraventricular Tachyarrhythmias.
In_Clinical_Trial_For
  • Locally Advanced or Metastatic Soft Tissue Sarcoma.
FDA_UNII_Code
  • E90NZP2L9U
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied as a treatment for cancer.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38332
PDQ_Closed_Trial_Search_ID
  • 38332
Chemical_Formula
  • C41H64O13
Legacy_Concept_Name
  • Digitoxin
CHEBI_ID
  • CHEBI:28544
FULL_SYN
  • CrystodiginBRNCI
  • CP4071PTNCI-GLOSSCDR0000045028
  • (3beta,5beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolidePTDCP01276
  • CP4071CNNCI
  • DIGITOXINPTFDAE90NZP2L9U
  • DigitoxinPTNCI
  • Crystalline DigitalinSYNCI
  • CardidiginSYNCI
DEFINITION
  • A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI)NCI
code
  • C2634
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