About: Tyrosine-Protein Phosphatase Non-Receptor Type 1     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tyrosine-Protein Phosphatase Non-Receptor Type 1
equivalentClass
OMIM_Number
  • 176885
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Tyrosine-Protein Phosphatase Non-Receptor Type 1
UMLS_CUI
  • C1335056
Legacy_Concept_Name
  • Non-Receptor_Type_1_Protein_Tyrosine_Phosphatase
FULL_SYN
  • EC 3.1.3.48SYNCI
  • PTPN1SYNCI
  • PTP-1BSYNCI
  • Tyrosine-Protein Phosphatase Non-Receptor Type 1PTNCI
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1SYNCI
  • Protein-Tyrosine Phosphatase 1BSYNCI
Swiss_Prot
  • P18031
DEFINITION
  • Tyrosine-protein phosphatase non-receptor type 1 (435 aa, ~50 kDa) is encoded by the human PTPN1 gene. This protein plays a role in endocytosis, the unfolded protein response, signaling and protein dephosphorylation.NCI
DesignNote
  • PTPN1 may dephosphorylate EGFR kinase, as well as JAK2 and TYK2 kinases, suggesting a role in cell growth control, and cell response to interferon stimulation. Oxidation of Cys-215 forms a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity; the active site is restored by reduction. (UniProt)
code
  • C26339
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