About: Growth Factor Receptor-Bound Protein 2     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Growth Factor Receptor-Bound Protein 2
equivalentClass
OMIM_Number
  • 108355
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • Growth Factor Receptor-Bound Protein 2
UMLS_CUI
  • C0170953
Legacy_Concept_Name
  • Growth_Factor_Receptor-Bound_Protein-2
FULL_SYN
  • ASH ProteinSYNCI
  • GRB2 ProteinSYNCI
  • GRB2SYNCI
  • GRB-2SYNCI
  • Growth Factor Receptor-Bound Protein 2PTNCI
  • Abundant SRC HomologySYNCI
Swiss_Prot
  • P29354
DEFINITION
  • GRB2 forms a complex with activated EGFR and the RAS-specific guanine nucleotide exchange factor SOS1, thereby mediating the growth factor-induced activation of RAS. It also acts to link PDGFRB to the Rac signaling pathway. Due to its ability to cause complex formation between proteins involved in growth signaling pathways, GRB2 has been referred to as an adaptor protein. (from LocusLink and OMIM)NCI
code
  • C26222
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