About: Toll-Like Receptor Family Gene     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Toll-Like Receptor Family Gene
rdfs:subClassOf
Semantic_Type
  • Gene or Genome
Preferred_Name
  • Toll-Like Receptor Family Gene
UMLS_CUI
  • C1336763
Legacy_Concept_Name
  • Toll-Like_Receptor_Family_Gene
FULL_SYN
  • Toll-Like Receptor Family GenePTNCI
DEFINITION
  • Expressed in a variety of tissues, Toll-Like Receptor Family Genes encode type I transmembrane Toll-Like Receptor proteins, containing a TIR domain and multiple LRR repeats, which respond to various microbial components and mediate pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLRs typically act via MyD88 (TIR interaction) and TRAF6, activating NF-Kappa-B, cytokine production and secretion, and inflammatory response. (NCI)NCI
code
  • C25965
is rdfs:subClassOf of
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