About: HER-2/neu Intracellular Domain Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • HER-2/neu Intracellular Domain Protein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • HER-2/neu Intracellular Domain Protein
UMLS_CUI
  • C3146228
PDQ_Open_Trial_Search_ID
  • 38047
PDQ_Closed_Trial_Search_ID
  • 38047
Legacy_Concept_Name
  • HER-2_neu_Intracellular_Domain_Protein
FULL_SYN
  • HER-2 ICD PeptideSYNCI
  • HER-2/neu Intracellular Domain ProteinPTNCI
  • HER-2/neu ICD ProteinSYNCI
DEFINITION
  • The cytoplasmic domain or intracellular domain (ICD) of the HER2/neu protein that exhibits tyrosine kinase activity. Based on sensitization theory, co-administration of trastuzumab (anti-HER-2/neu monoclonal antibody) and HER-2/neu intracellular domain protein may result in the potentiation of a HER2/neu-specific cytotoxic T lymphocyte (CTL) response against tumor cells overexpressing the HER2/neu protein. HER-2/neu protein, a glycoprotein cell surface receptor that is composed of an extracellular domain (ECD), a transmembrane domain, and an ICD, is overexpressed by many adenocarcinomas including breast adenocarcinoma.NCI
code
  • C2593
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