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AttributesValues
rdf:type
rdfs:label
  • Indisulam
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Indisulam
UMLS_CUI
  • C1099211
CAS_Registry
  • 165668-41-7
FDA_UNII_Code
  • WJ98J3NM90
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that belongs to the family of drugs called sulfonamides. It is being studied for its ability to treat cancer.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43559
PDQ_Closed_Trial_Search_ID
  • 43559
Chemical_Formula
  • C14H12ClN3O4S2
Legacy_Concept_Name
  • E7070
FULL_SYN
  • E7070PTNCI-GLOSSCDR0000046718
  • N-(3-Chloro-7-indoyl)-1,4-BenzenedisulfonamideSNNCI
  • E7070CNNCI
  • INDISULAMPTFDAWJ98J3NM90
  • IndisulamPTNCI
DEFINITION
  • A novel sulfonamide compound with potential antineoplastic activity. Indisulam inhibits cyclin-dependent kinases (CDK), which regulate cell cycle progression and are usually over-expressed in cancerous cells. Inhibition of CDK results in G1/S phase arrest of the cell cycle, and may lead to induction of apoptosis and inhibition of tumor cell proliferation. In addition, indisulam also inhibits carbonic anhydrases (CA), especially isoforms IX and XII that are involved in aqueous humor production and are highly overexpressed in some types of cancers. Inhibition of CA IX and XII results in interference with ion exchange and pH in hypoxic tumor tissue and preventing chemoresistance to weakly basic antineoplastic agents.NCI
code
  • C25797
is someValuesFrom of
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